Peter Reynolds

The life and times of Peter Reynolds

Posts Tagged ‘cannabis

There Is No Scientific Evidence That Cannabis Cures Cancer In Humans – Yet.

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cannabis oil in syringe

Cannabis Oil

Most of the evidence concerning cannabis and cancer is in vitro or in vivo (animals). There is virtually none in humans, only human cell lines in petri dishes. There is no evidence of a curative effect. The only clinical trial was purified THC fed directly into glioma brain tumours in nine patients. Eight showed some benefit but all were dead within one year.

The evidence almost certainly will come but it does not yet exist and may require specific extracts, concentrates or other processes to produce reliable, consistent, clinical results.

This is a pre-publication extract from ‘Medicinal Cannabis:The Evidence’, the most comprehensive and up to date review of the evidence on medicinal cannabis, shortly to be published by CLEAR.

Studies And Clinical Trials

Cancer

The anti cancer properties of THC, CBD, CBG and other cannabinoids are well established.  Scientists have been investigating them since the early 1970s and more than 1100 papers on cannabinoids and cancer have been published. (42)

It is also well established that cannabis helps with the side effects of cancer treatments, particularly nausea and lack of appetite. (43,44,45,46)

Cannabis may also help alleviate anxiety, depression, insomnia and mood disorders in cancer patients.  However, some patients may find exactly the opposite results (47)

A very large quantity of anecdotal reports detail remarkable results with cannabis oil on many different forms of cancer. (48) One of the most important properties of cannabis as a cancer therapy is that it is non-toxic and even if little therapeutic effect is achieved, it causes little harm.

On balance, while there is good evidence of anti cancer properties in vitro (human cell lines) and in vivo (animal) studies, there is little evidence of actual results in humans except in the treatment of basal cell carcinoma (49). However, few would disagree that the palliative value of cannabis is of great benefit to many cancer patients. (50)

Clinical trials are underway on cancer pain (51) and the treatment of glioma brain cancer (52).

These selected studies indicate the evidence currently available.

Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581 (53)

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html (54)

Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339 (55)

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long (56)

The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext (57)

Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349 (58)

Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283 (59)

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/ (60)

Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs (61)

Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20 (62)

Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/ (63)

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955 (64)

References

42. PubMed search term ‘cannabinoid cancer’ http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer

43. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

44. Cannabinoids in medicine: A review of their therapeutic potential. JEthPharm, 2006. http://www.ww.ufcw770.org/sites/all/themes/danland/files/CannabinoidsMedMetaAnalysis06.pdf

45. Review on clinical studies with cannabis and cannabinoids 2005-2009. IACM 2010. http://www.cannabis-med.org/data/pdf/en_2010_01_special.pdf

46. Medical marijuana for cancer. CA: A Cancer Journal for Clinicians, 2014. http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/abstract

47. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

48. Cannabis Oil Testimonials. Cure Your Own Cancer, 2014. http://www.cureyourowncancer.org/testimonials.html

49. Physician’s documentation confirms successful treatment of basal cell carcinoma resulted from the application of a topical cannabis extract. Cannabis Science, 2011. http://www.cannabisscience.com/2011/499-cannabis-science-provides-physician-s-documentation-that-confirms-successful-treatment-of-skin-cancer

50. Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity. AM J HOSP PALLIAT CARE, 2011. http://ajh.sagepub.com/content/28/5/297

51. Third phase III Sativex cancer pain trial commences http://www.gwpharm.com/Third%20phase%20III%20Sativex%20cancer%20pain%20trial%20commences.aspx

52. GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM) http://is.gd/Wac81a

53. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581

54. A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html

55. Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339

56. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long

57. The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext

58. Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349

59. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283

60. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/

61. Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs

62. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20

63. Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/

64. The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955

Written by Peter Reynolds

March 25, 2015 at 9:29 am

The BBC Finally Wakes Up To the Potential Of Medicinal Cannabis.

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bbc cannab headerSome people think the BBC is right wing and others think it’s run by a bunch of commie subversives.  Personally I’d say it’s soft left, mumsy, pro-status quo.  It supports the establishment and that means it’s always been negative about cannabis.  If it isn’t joining in the demonisation of us – the three million psychotic axe murderers that use cannabis regularly in the UK – then it takes a jokey, sarcastic, snide angle.

Alistair Leithead.

Alistair Leithead

So the release of a short news video report today ‘Can cannabis oil cure serious diseases like cancer?’ is a big step forward.  Even better, it’s fronted by Alastair Leithead, a credible, intelligent journalist, not by some ‘celebrity doctor’ or the ‘addiction expert’ Professor John Marsden, who presented the disgraceful and misleading ‘America’s Stoned Kids’ in 2012, where he tried to pin adolescents with cannabis problems on Colorado’s legalisation even though it hadn’t even come into force at the time.

Professor

Professor John Marsden

Mark my words, this is a step change, a seminal moment.

Perhaps, at last, the UK media will start treating medicinal cannabis seriously as has been happening in America and Australia for many years.  We’ve already seen some local newspapers publishing intelligent articles and the Daily Mail has jumped on the bandwagon of sensationalist stories about treating childhood epilepsy.  All we need now is The Times, The Guardian and the Sundays to give it the attention it deserves.  The Daily Telegraph has become the new home of ‘reefer madness’, with appalling distortion of science, more tabloid than a tabloid.  But we don’t need it anymore, it’s made itself irrelevant.

bbc cannabis oil 2bbc cannabis oilSo watch this short video.  It includes interviews with Kat Arney of Cancer Research UK, a woman who is cancer free after rejecting chemotherapy and only using cannabis oil and a sceptical Professor David Agus, who is entirely correct that there is no credible scientific evidence yet available that cannabis cures cancer.

It’s coming though.  CLEAR is about to publish the most comprehensive, up to date paper ‘Medicinal Cannabis:The Evidence’.  A leading pharmacologist is about to publish a paper supporting a move of cannabis from schedule one to schedule two and various clinical trials are coming to fruition.

All the more reason to be optimistic that the next Parliament will have no option but to introduce long-overdue reform.

For All The Hysteria About Cannabis And Psychosis, Here Are The Facts.

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Charles Walker MP. A Scaremonger Without A Cause.

Charles Walker MP. A Scaremonger Without A Cause.

Charles Walker MP, Parliament’s cheerleader for the ‘skunk scaremongerers’ shot himself and his hysterical campaign in the foot yesterday.

He had submitted a parliamentary written question asking:

“…how many people under 18 years of age have been treated in NHS-funded mental health units for cannabis-induced psychosis in each of the last five years?”

The answer from Jane Ellison MP, minister of state at the Department of Health, must have gravely disappointed Mr Walker.  She revealed there have been average of just over 28 ‘finished admission episodes’ for each of the past five years.  That doesn’t necessarily mean 28 people as it could include the same person being admitted more than once.

Of course, each of these 28 cases is a tragedy for the people involved and nothing must distract from that but it clearly shows that in public health terms, ‘cannabis psychosis’ (which some senior psychiatrists don’t even believe is a genuine diagnosis) is virtually unheard of.  So much for the endless newspaper columns, the endlessly repeated ‘studies’ that never reach any conclusion and the endless moralising and deceit from those who make money from this scare story – either from providing ‘therapy’ or by fleecing money from those prepared to fund so-called science that sets out to reach a pre-determined conclusion.

Of course, not only are these cases very, very few in number but they have arisen under the present policy of prohibition when the market is in the hands of criminals.  How much could we reduce this number if government took a responsible approach and regulated the market?  With proper quality control, age limits, better education and harm reduction surely we could make the cannabis market safer than it is in the hands of the criminal underworld?

Dr Trevor Turner, Consultant Psychiatrist

Dr Trevor Turner, Consultant Psychiatrist

“I don’t think it causes mental illness. I have never seen a case of so-called cannabis psychosis.”

Dr Trevor Turner, East London and City University Mental Health NHS Trust

 

So this is very, very bad news for Charles Walker, for his sponsor, Mary Brett of ‘Cannabis Skunk Sense’, for Peter Hitchens, David Raynes, Sarah Graham, Theresa May and hundreds of rehab clinics, therapists and charlatans who talk up the cannabis psychosis scare story.  The Daily Mail and the Daily Telegraph, which systematically misrepresent and distort evidence on the subject are exposed for what they are. Even those on the reform side like Transform, who have chosen the dubious path of talking up cannabis as ‘dangerous’ in order to sell their consultancy services, are disgraced.  Their credibility is destroyed.  Their argument is false and it always has been.

The husband and wife team of Professor Sir Robin Murray and Dr Marta Di Fiori, have built up a family business in skunk scaremongering.  Every year they release another ‘study’ which says almost exactly the same as the last one, never shows any causative effect but is relentlessly exaggerated and regurgitated for those who want to demonise cannabis and cannabis users.  Their last point is always ‘more research is needed’.  I wonder is there anyone stupid enough out there to continue funding this vendetta against the three million people in the UK that enjoy cannabis or use it as medicine?  Similarly in Australia, Professor Wayne Hall and his colleagues at the National Cannabis Prevention and Information Centre, have built their careers and made a lot of money pursuing this futile goal of proof that cannabis cause mental illness.  The figures prove them all wrong. They are all self-serving propagandists and deceivers, nothing more.

These figures are more than evidence, they are facts and they prove that ‘cannabis psychosis’ is such an infinitesimally small risk, that we really need to stop wasting so much time, energy and money on it. We need to get on, legalise, regulate and start bringing the market under proper control, stop wasting money on futile law enforcement and research and start generating tax revenue and providing therapeutic and financial benefits for the whole community.

A Day In Cambridge On Drugs.

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Homerton College, Cambridge.

Homerton College, Cambridge.

George and Dean were where I expected them to be.  In the car park, ‘medicating’ in order to get them through a long afternoon.

The Home Affairs Select Committee (HASC) Drugs Conference took place in the delightful surroundings of Homerton College, Cambridge.  I know there were several others there who were only able to make it because they committed criminal offences in order to maintain their health.  I attended with George Hutchings and Dean Price, leading members of the CLEAR Medicinal Cannabis Users Panel.

Almost everybody who is anybody in UK drugs policy was there and while there were no groundbreaking new revelations or ideas, it was an important occasion.  It marked the current position of the debate on drugs policy in Britain at the end of the first coalition government since 1945. As Keith Vaz, chair of the HASC, said, the conference will influence the drugs policy agenda in the next government.

I know I wasn’t the only person who lobbied in advance for medicinal cannabis to be included in the conference programme.  It wasn’t but what was of enormous significance was that it was probably the single issue mentioned most often, time and time again in fact, throughout the day. I trust that the committee will take this on board and ensure that in any future event, it is given proper attention.

Dr Julian Huppert MP; Lynne Featherstone MP, Minister;Keith Vaz MP, Dr Roberto Dondisch, Danny Kushlick

Dr Julian Huppert MP, Lynne Featherstone MP, Keith Vaz MP, Dr Roberto Dondisch, Baroness Molly Meacher, Danny Kushlick

It’s no good saying it’s a health issue because until the Home Office releases its stranglehold on the throats of the thousands who need medicinal cannabis, it’s the HASC that needs to hold the government to account. CLEAR estimates that around one million people already use cannabis for medicinal reasons in the UK.  This equates closely to the proportion of medicinal users in jurisdictions where there is some degree of legal access.

Julian Huppert mentioned medicinal cannabis in his review of the HASC’s work, confirming that the Liberal Democrats have adopted the policy advanced by CLEAR almost word for word.

Baroness Molly Meacher made an impassioned plea for medicinal cannabis access in her address, expressing her anger and outrage that people are denied the medicine they need.

Jonathan Liebling, of United Patients Alliance, and I also raised the issue independently in questions from the floor. I also dealt with Professor Neil McKeganey’s attempt to dismiss the issue.  He claimed that there are perfectly satisfactory procedures for licensing medicines.  I explained how cannabis cannot be regulated like single-molecule pharmaceutical products and gave a brief description of research on the ‘entourage effect’.

The Home Office minister, Lynne Featherstone, gave the keynote speech and I was delighted that she chose to mention her meeting ten days ago with a CLEAR medicinal users delegation.

David Nutt was as wise and authoritative as ever . Then Neil McKeganey launched into an entertaining rant about how the conference programme, the speakers and delegates were massively biased in favour of reform.  He claimed that this was not a proper reflection of the evidence or nationwide opinion.

I like Neil, even though we are on opposite sides of the debate. In fact, at events like this I prefer to engage with the opposition rather than back-slapping and self-affirming chats with those on the side of reform. I also had good informal discusions with David Raynes of the National Drug Prevention Alliance and Sarah Graham, the magnet-wielding addiction therapist.

Tom Lloyd’s speech was inspiring.  He also made a powerful case for medicinal cannabis and as ex-chief constable of Cambridge, it was extraordinary to see him lambast the new drug driving law as “…outrageous…unjust…will criminalise people who are in no way impaired…”

The final speech was given by Mike Trace, chair of the International Drug Policy Consortium, who is deeply involved in preparing for the UN General Assembly Special Session in 2016 on drugs policy.

So, a fascinating and worthwhile day.  All we need to do now is get through the General Election.  In about two months we will know where we are and unless we have the disaster of a Tory or Labour majority government, then drug policy reform should be high on the agenda.

A Sad Day When Drug Reformers Capitulate to The Evidence-Free Claim: ‘Drugs Are Dangerous’.

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Transform released this astonishing video two days ago, on 9th March 2015.  It is astonishing because it is so fundamentally flawed and it represents a betrayal of the values for which so many have supported Transform’s work over so many years.

Drugs are not dangerous, certainly not cannabis.

This is a straw man argument, now fundamental to the strategy of Transform, the UK’s most generously funded drugs policy group. They build up the harms of drugs, falsely, without evidence, in order to be able to ride in on their white stallions and rescue us from this imaginary danger.

So now they do the job of the prohibitionists for us.  They have bought right into this inaccurate and misleading mindset and Transform is now promoting drugs as dangerous.  Transform is adding to the messages and media storm from the tabloids, ignorant politicians and the moralising hypocrites that drive the war on drugs.

Are cars dangerous? Is a bottle of vodka dangerous?

Only if they are misused or abused and then they are both far more dangerous than cannabis.

Cannabis doesn’t need to be regulated because it is dangerous.  It needs to be regulated because prohibition is dangerous and causes far more harm than cannabis ever has or ever will.

At least 95% of cannabis use is harmless and without risk.  It is a miniscule proportion of people who are in danger of any harm.  They begin using cannabis at a young age, use it heavily, daily, have a genetic predisposition to mental health issues and will have other component factors in their life such as other drugs (particularly alcohol), life events, family problems, etc.  All the research shows that cannabis is never more than just one factor amongst a complex mix that leads to mental illness.

Danny Kushlick, Transform: "Cannabis Is Dangerous"

Danny Kushlick, Transform: “Cannabis Is Dangerous”

Last year Danny Kushlick, also of Transform, came out with this nonsense that ‘cannabis is dangerous’.  I wrote about it then: Cannabis is Neither ‘Harmless’ Nor ‘Dangerous’. Now, in this latest video, Steve Rolles confirms this misguided, self-defeating path that Transform is embarked on.

I remember, just a few years ago, Steve arguing that even most cocaine use is without harm and he was right. Millions use cocaine every day and only a very few slip into dependency or a self-destructive use pattern.  It isn’t as safe as cannabis but it’s probably no more harmful than alcohol.

So why is Transform set on this course?  Next thing we’ll have leading scientists adopting the same terminology – ‘skunk’ – as the tabloids use to demonise cannabis… Oh yes, it’s already happened.

All organisations become self-serving unless they have active shareholders or members to keep them on track.  In my opinion, those leading Transform should remember how and why they started and I think it was mainly about truth, about combating the lies, misinformation and propaganda that the drug war is based on.

Transform needs to get back to the truth.

To sum up, I quote the very wise words of Lee Prew, a CLEAR member and a man who has his eye on the ball.

“Is it just me or are drug reformers like Transform and The Beckley Foundation part of the misinformation that dominates this country’s lack of understanding and honesty towards drugs? If these people that support positive changes to our system can’t even get the facts right what hope do we really stand of achieving workable drugs policies?

If they believe that simplification of terminology (skunk & hash) and catch all statements like “drugs are dangerous” are in any way helpful to the situation they are wrong. The drug issue is a complicated one with many facets (as we can see with cannabis alone) and by simplifying the situation they only go to undermine their own work. Very worrying.”

Written by Peter Reynolds

March 11, 2015 at 9:47 pm

A Vision Of The Future Of Cannabis.

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Written by Peter Reynolds

March 6, 2015 at 8:49 pm

Channel 4 Drugs Live. How To Cause Confusion About Cannabis.

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Hash

Hash

What is this ‘hash’ that looks like weed and this ‘skunk’ that isn’t cannabis?

Channel 4’s ‘Drugs Live:Cannabis On Trial‘ played fast and loose with facts, terminology and ethical considerations.

Cannabis

Cannabis

To be fair, I greatly enjoyed the programme (well I would wouldn’t I) and there was some fascinating science. Particularly about how the brain responds to music when you’re high and about how CBD protects the ‘salience network’, the key to motivation.  This gives weight to the theory of an ‘amotivational syndrome’.

In a week’s time though, all that most of the public will remember is Jon Snow saying that using ‘skunk’ was more terrifying than being in a war zone and his distorted reporting of the recent study by which he implied that 25% of people who use ‘skunk’ will become psychotic.

So I am left with very mixed feelings.  The pre-publicity was a disgrace: inaccurate, misleading, unethical  – words I have already published and I stand by them.

The brazen misuse of the terms ‘skunk’ and ‘hash’ is an appalling error of judgement by Channel 4, Renegade Pictures and yes, sadly, by two scientists for whom I have the greatest  of respect: Professors Val Curran and David Nutt.

Why would you choose to use the same word as the gutter press chooses to demonise cannabis? ‘Skunk’ is a scary word and what it really means is a sativa dominant strain with a modest THC content of 8% and only traces of CBD.

As for hash, it also has a specific meaning: the compressed resin, derived from the plant by sieving or by hand rubbing.  By definition a more concentrated form of cannabis, yet the programme claimed exactly the opposite.

A far better, more accurate, more scientific and informative shorthand would have been to describe the cannabis as low CBD, high CBD and placebo.

Surely, whether we agree or disagree with their evidence, we are entitled to expect precision and accuracy from scientists?

The fundamental problem with this programme was that there were no cannabis experts present, only detached academics and scientists or cannabis users who were hardly well informed or articulate.  I did of course volunteer but for some reason the producers saw fit to exclude anyone from the cannabis campaign or anyone who has both in depth knowledge and real experience.

Unfortunately, this programme will go the same way as all those other earnest endeavours, ‘The Union’, ‘The Culture High’, ‘In Pot We Trust’, etc – all very enjoyable, self-affirming and satisfying but all preaching to the choir. I’ll be interested to see what the viewing figures were for last night’s programme.

Professor David Nutt and his Harm Index.

Professor David Nutt and his Harm Index.

The best bit was David Nutt’s final conclusion. On his scale of harms, even low CBD cannabis (the demon ‘SKUNK’)  is less harmful than alcohol, heroin, crack, meth, cocaine, tobacco and speed.  After the study he concludes that high CBD cannabis is the least harmful drug of all.

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