Peter Reynolds

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There Is No Scientific Evidence That Cannabis Cures Cancer In Humans – Yet.

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cannabis oil in syringe

Cannabis Oil

Most of the evidence concerning cannabis and cancer is in vitro or in vivo (animals). There is virtually none in humans, only human cell lines in petri dishes. There is no evidence of a curative effect. The only clinical trial was purified THC fed directly into glioma brain tumours in nine patients. Eight showed some benefit but all were dead within one year.

The evidence almost certainly will come but it does not yet exist and may require specific extracts, concentrates or other processes to produce reliable, consistent, clinical results.

This is a pre-publication extract from ‘Medicinal Cannabis:The Evidence’, the most comprehensive and up to date review of the evidence on medicinal cannabis, shortly to be published by CLEAR.

Studies And Clinical Trials

Cancer

The anti cancer properties of THC, CBD, CBG and other cannabinoids are well established.  Scientists have been investigating them since the early 1970s and more than 1100 papers on cannabinoids and cancer have been published. (42)

It is also well established that cannabis helps with the side effects of cancer treatments, particularly nausea and lack of appetite. (43,44,45,46)

Cannabis may also help alleviate anxiety, depression, insomnia and mood disorders in cancer patients.  However, some patients may find exactly the opposite results (47)

A very large quantity of anecdotal reports detail remarkable results with cannabis oil on many different forms of cancer. (48) One of the most important properties of cannabis as a cancer therapy is that it is non-toxic and even if little therapeutic effect is achieved, it causes little harm.

On balance, while there is good evidence of anti cancer properties in vitro (human cell lines) and in vivo (animal) studies, there is little evidence of actual results in humans except in the treatment of basal cell carcinoma (49). However, few would disagree that the palliative value of cannabis is of great benefit to many cancer patients. (50)

Clinical trials are underway on cancer pain (51) and the treatment of glioma brain cancer (52).

These selected studies indicate the evidence currently available.

Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581 (53)

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html (54)

Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339 (55)

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long (56)

The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext (57)

Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349 (58)

Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283 (59)

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/ (60)

Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs (61)

Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20 (62)

Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/ (63)

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955 (64)

References

42. PubMed search term ‘cannabinoid cancer’ http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer

43. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

44. Cannabinoids in medicine: A review of their therapeutic potential. JEthPharm, 2006. http://www.ww.ufcw770.org/sites/all/themes/danland/files/CannabinoidsMedMetaAnalysis06.pdf

45. Review on clinical studies with cannabis and cannabinoids 2005-2009. IACM 2010. http://www.cannabis-med.org/data/pdf/en_2010_01_special.pdf

46. Medical marijuana for cancer. CA: A Cancer Journal for Clinicians, 2014. http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/abstract

47. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

48. Cannabis Oil Testimonials. Cure Your Own Cancer, 2014. http://www.cureyourowncancer.org/testimonials.html

49. Physician’s documentation confirms successful treatment of basal cell carcinoma resulted from the application of a topical cannabis extract. Cannabis Science, 2011. http://www.cannabisscience.com/2011/499-cannabis-science-provides-physician-s-documentation-that-confirms-successful-treatment-of-skin-cancer

50. Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity. AM J HOSP PALLIAT CARE, 2011. http://ajh.sagepub.com/content/28/5/297

51. Third phase III Sativex cancer pain trial commences http://www.gwpharm.com/Third%20phase%20III%20Sativex%20cancer%20pain%20trial%20commences.aspx

52. GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM) http://is.gd/Wac81a

53. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581

54. A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html

55. Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339

56. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long

57. The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext

58. Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349

59. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283

60. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/

61. Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs

62. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20

63. Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/

64. The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955

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Written by Peter Reynolds

March 25, 2015 at 9:29 am

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