Peter Reynolds

The life and times of Peter Reynolds

There Is No Scientific Evidence That Cannabis Cures Cancer In Humans – Yet.

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cannabis oil in syringe

Cannabis Oil

Most of the evidence concerning cannabis and cancer is in vitro or in vivo (animals). There is virtually none in humans, only human cell lines in petri dishes. There is no evidence of a curative effect. The only clinical trial was purified THC fed directly into glioma brain tumours in nine patients. Eight showed some benefit but all were dead within one year.

The evidence almost certainly will come but it does not yet exist and may require specific extracts, concentrates or other processes to produce reliable, consistent, clinical results.

This is a pre-publication extract from ‘Medicinal Cannabis:The Evidence’, the most comprehensive and up to date review of the evidence on medicinal cannabis, shortly to be published by CLEAR.

Studies And Clinical Trials

Cancer

The anti cancer properties of THC, CBD, CBG and other cannabinoids are well established.  Scientists have been investigating them since the early 1970s and more than 1100 papers on cannabinoids and cancer have been published. (42)

It is also well established that cannabis helps with the side effects of cancer treatments, particularly nausea and lack of appetite. (43,44,45,46)

Cannabis may also help alleviate anxiety, depression, insomnia and mood disorders in cancer patients.  However, some patients may find exactly the opposite results (47)

A very large quantity of anecdotal reports detail remarkable results with cannabis oil on many different forms of cancer. (48) One of the most important properties of cannabis as a cancer therapy is that it is non-toxic and even if little therapeutic effect is achieved, it causes little harm.

On balance, while there is good evidence of anti cancer properties in vitro (human cell lines) and in vivo (animal) studies, there is little evidence of actual results in humans except in the treatment of basal cell carcinoma (49). However, few would disagree that the palliative value of cannabis is of great benefit to many cancer patients. (50)

Clinical trials are underway on cancer pain (51) and the treatment of glioma brain cancer (52).

These selected studies indicate the evidence currently available.

Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581 (53)

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html (54)

Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339 (55)

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long (56)

The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext (57)

Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349 (58)

Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283 (59)

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/ (60)

Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs (61)

Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20 (62)

Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/ (63)

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955 (64)

References

42. PubMed search term ‘cannabinoid cancer’ http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer

43. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

44. Cannabinoids in medicine: A review of their therapeutic potential. JEthPharm, 2006. http://www.ww.ufcw770.org/sites/all/themes/danland/files/CannabinoidsMedMetaAnalysis06.pdf

45. Review on clinical studies with cannabis and cannabinoids 2005-2009. IACM 2010. http://www.cannabis-med.org/data/pdf/en_2010_01_special.pdf

46. Medical marijuana for cancer. CA: A Cancer Journal for Clinicians, 2014. http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/abstract

47. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5

48. Cannabis Oil Testimonials. Cure Your Own Cancer, 2014. http://www.cureyourowncancer.org/testimonials.html

49. Physician’s documentation confirms successful treatment of basal cell carcinoma resulted from the application of a topical cannabis extract. Cannabis Science, 2011. http://www.cannabisscience.com/2011/499-cannabis-science-provides-physician-s-documentation-that-confirms-successful-treatment-of-skin-cancer

50. Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity. AM J HOSP PALLIAT CARE, 2011. http://ajh.sagepub.com/content/28/5/297

51. Third phase III Sativex cancer pain trial commences http://www.gwpharm.com/Third%20phase%20III%20Sativex%20cancer%20pain%20trial%20commences.aspx

52. GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM) http://is.gd/Wac81a

53. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581

54. A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html

55. Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339

56. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long

57. The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext

58. Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349

59. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283

60. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/

61. Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs

62. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20

63. Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/

64. The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955

Written by Peter Reynolds

March 25, 2015 at 9:29 am

The BBC Finally Wakes Up To the Potential Of Medicinal Cannabis.

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bbc cannab headerSome people think the BBC is right wing and others think it’s run by a bunch of commie subversives.  Personally I’d say it’s soft left, mumsy, pro-status quo.  It supports the establishment and that means it’s always been negative about cannabis.  If it isn’t joining in the demonisation of us – the three million psychotic axe murderers that use cannabis regularly in the UK – then it takes a jokey, sarcastic, snide angle.

Alistair Leithead.

Alistair Leithead

So the release of a short news video report today ‘Can cannabis oil cure serious diseases like cancer?’ is a big step forward.  Even better, it’s fronted by Alastair Leithead, a credible, intelligent journalist, not by some ‘celebrity doctor’ or the ‘addiction expert’ Professor John Marsden, who presented the disgraceful and misleading ‘America’s Stoned Kids’ in 2012, where he tried to pin adolescents with cannabis problems on Colorado’s legalisation even though it hadn’t even come into force at the time.

Professor

Professor John Marsden

Mark my words, this is a step change, a seminal moment.

Perhaps, at last, the UK media will start treating medicinal cannabis seriously as has been happening in America and Australia for many years.  We’ve already seen some local newspapers publishing intelligent articles and the Daily Mail has jumped on the bandwagon of sensationalist stories about treating childhood epilepsy.  All we need now is The Times, The Guardian and the Sundays to give it the attention it deserves.  The Daily Telegraph has become the new home of ‘reefer madness’, with appalling distortion of science, more tabloid than a tabloid.  But we don’t need it anymore, it’s made itself irrelevant.

bbc cannabis oil 2bbc cannabis oilSo watch this short video.  It includes interviews with Kat Arney of Cancer Research UK, a woman who is cancer free after rejecting chemotherapy and only using cannabis oil and a sceptical Professor David Agus, who is entirely correct that there is no credible scientific evidence yet available that cannabis cures cancer.

It’s coming though.  CLEAR is about to publish the most comprehensive, up to date paper ‘Medicinal Cannabis:The Evidence’.  A leading pharmacologist is about to publish a paper supporting a move of cannabis from schedule one to schedule two and various clinical trials are coming to fruition.

All the more reason to be optimistic that the next Parliament will have no option but to introduce long-overdue reform.

This Violent Thug Needs To Be Arrested, Charged And Imprisoned.

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Dan Glass, Scumbag. Given Airtime By The BBC.

Dan Glass, Scumbag. Given Airtime By The BBC.

I am not a UKIP voter.  I don’t have to be to deplore the violence, harassment and abuse levelled at Nigel Farage and his family when yesterday they went to their local pub, the Queen’s Head in Downe, Kent, for Sunday lunch.

‘Scum’, the word that Farage used to describe the attackers, is really too good for the ringleader Dan Glass.  He is a thug, a child abuser, an organiser and promoter of violence and a prime example of the sort of despicable, lefty creep that this country needs rid of.  Can’t we send him to Syria, Iraq or Libya where he can associate with the sort of subhuman detritus whose ideas and attitudes he shares?

Farage’s wife Kirsten and his children: Victoria, 15 and Isabelle, 10, fled in fear when the attack started.  I don’t know whether the police were notified yesterday but they have been now because I have reported it.

Glass is in the business of conspiring, organising and promoting violent and unlawful actions as his repellent website shows: http://www.theglassishalffull.co.uk/

In the most ludicrous display of hypocrisy he claims:

“Our aim is to build a world of peace, collaboration and justice.”

I’ve got news for you boy, in order to achieve those aims you need to turn yourself in, along with all the obnoxious pond life that you led in your violent attack yesterday.

As for the BBC giving him a platform on the Daily Politics, just another nail in the coffin of our once great national broadcaster that is now a model of incompetence and bad judgement.

 

Written by Peter Reynolds

March 23, 2015 at 4:45 pm

People Of Different Colours.

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group-of-people diff colours

Can somebody please explain to me why it is regarded as racist to call somebody ‘coloured’ but perfectly acceptable, even cool and hip, to say ‘people of colour’?

Answers in the comments please.  Even politically-correct lefties are welcome to contribute.

Written by Peter Reynolds

March 22, 2015 at 10:37 am

Posted in Politics

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For All The Hysteria About Cannabis And Psychosis, Here Are The Facts.

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Charles Walker MP. A Scaremonger Without A Cause.

Charles Walker MP. A Scaremonger Without A Cause.

Charles Walker MP, Parliament’s cheerleader for the ‘skunk scaremongerers’ shot himself and his hysterical campaign in the foot yesterday.

He had submitted a parliamentary written question asking:

“…how many people under 18 years of age have been treated in NHS-funded mental health units for cannabis-induced psychosis in each of the last five years?”

The answer from Jane Ellison MP, minister of state at the Department of Health, must have gravely disappointed Mr Walker.  She revealed there have been average of just over 28 ‘finished admission episodes’ for each of the past five years.  That doesn’t necessarily mean 28 people as it could include the same person being admitted more than once.

Of course, each of these 28 cases is a tragedy for the people involved and nothing must distract from that but it clearly shows that in public health terms, ‘cannabis psychosis’ (which some senior psychiatrists don’t even believe is a genuine diagnosis) is virtually unheard of.  So much for the endless newspaper columns, the endlessly repeated ‘studies’ that never reach any conclusion and the endless moralising and deceit from those who make money from this scare story – either from providing ‘therapy’ or by fleecing money from those prepared to fund so-called science that sets out to reach a pre-determined conclusion.

Of course, not only are these cases very, very few in number but they have arisen under the present policy of prohibition when the market is in the hands of criminals.  How much could we reduce this number if government took a responsible approach and regulated the market?  With proper quality control, age limits, better education and harm reduction surely we could make the cannabis market safer than it is in the hands of the criminal underworld?

Dr Trevor Turner, Consultant Psychiatrist

Dr Trevor Turner, Consultant Psychiatrist

“I don’t think it causes mental illness. I have never seen a case of so-called cannabis psychosis.”

Dr Trevor Turner, East London and City University Mental Health NHS Trust

 

So this is very, very bad news for Charles Walker, for his sponsor, Mary Brett of ‘Cannabis Skunk Sense’, for Peter Hitchens, David Raynes, Sarah Graham, Theresa May and hundreds of rehab clinics, therapists and charlatans who talk up the cannabis psychosis scare story.  The Daily Mail and the Daily Telegraph, which systematically misrepresent and distort evidence on the subject are exposed for what they are. Even those on the reform side like Transform, who have chosen the dubious path of talking up cannabis as ‘dangerous’ in order to sell their consultancy services, are disgraced.  Their credibility is destroyed.  Their argument is false and it always has been.

The husband and wife team of Professor Sir Robin Murray and Dr Marta Di Fiori, have built up a family business in skunk scaremongering.  Every year they release another ‘study’ which says almost exactly the same as the last one, never shows any causative effect but is relentlessly exaggerated and regurgitated for those who want to demonise cannabis and cannabis users.  Their last point is always ‘more research is needed’.  I wonder is there anyone stupid enough out there to continue funding this vendetta against the three million people in the UK that enjoy cannabis or use it as medicine?  Similarly in Australia, Professor Wayne Hall and his colleagues at the National Cannabis Prevention and Information Centre, have built their careers and made a lot of money pursuing this futile goal of proof that cannabis cause mental illness.  The figures prove them all wrong. They are all self-serving propagandists and deceivers, nothing more.

These figures are more than evidence, they are facts and they prove that ‘cannabis psychosis’ is such an infinitesimally small risk, that we really need to stop wasting so much time, energy and money on it. We need to get on, legalise, regulate and start bringing the market under proper control, stop wasting money on futile law enforcement and research and start generating tax revenue and providing therapeutic and financial benefits for the whole community.

No Decent Briton Can Vote For A Man Who Supports Netanyahu, The War Criminal.

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David Cameron visit to Israel and Palestine

Cameron’s support for Netanyahu makes him complicit in genocide, child murder, apartheid, land theft and other war crimes.  Whatever domestic issues we may be concerned with, this is of another magnitude and is an unforgiveable act of treason against mankind.

The best policy for Netanyahu is assassination.  It is a moral and ethical choice to obliterate this monster from the planet without endangering any lives except those of our heroic special forces who must undertake this mission.  If Netanyahu escapes this justice and is dragged in chains to the Hague to face trial, Cameron should be taken with him as an accomplice.

Written by Peter Reynolds

March 19, 2015 at 9:49 am

Posted in Politics

Tagged with , , ,

The BBC Is Dead. Long Live Jeremy Clarkson.

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DAILY MAIL: “…senior BBC boss claims ‘Clarkson is like Savile'”

Jeremy Clarkson

Jeremy Clarkson

OK, well it is the Daily Mail, so until there’s some corroboration we should be cautious about believing it. However, if there is even an iota of truth in it then the ‘BBC boss’ must be sacked. That’s sacked, not ‘allowed to resign’ or ‘retire’.  He or she must be summarily dismissed without compensation.

This could also be the chance to exceed the record libel award in the High Court.  What can be more defamatory in 2015 than comparing someone to the bogey man to end all bogey men, Jimmy Savile?

I really think this is the end for the BBC now. Relentless incompetence, far too many wildly overpaid apparatchiks.  A culture of a soft left, pro status quo, subservient to orders from ministers and civil servants, however much it might protest its faux independence from government.  My personal grudge: the craven censorship even of any debate on drugs policy.

As for Jezza, it amazes me how so many people don’t understand that he is in the business of satire and irony. Either they’re dumb, ‘frigid feminist PC bigots’ (Jezza would be proud of me) or they are lacking in any humour or intelligent understanding of the self-parody that is Jeremy Clarkson. He’s a hoot and he deserves the support he has gained from ‘probably the fastest growing petition ever in the history of the world’

Of course, if he hit someone then he should be subject to disciplinary and possibly criminal process.  On the other hand, if it was a minor fracas and argument between colleagues then the BBC is guilty once again of dreadful misjudgement.

I greatly admire the BBC’s output and it has been a wonderful training ground for our richest talent in film, TV and radio but it is now time for  it to be broken up. We won’t lose the talent or the high quality creative and production skills but we must lose the dishonest culture, sense of entitlement and attitudes that belong to a bygone era.

Written by Peter Reynolds

March 15, 2015 at 1:47 pm

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